Promifen (Clomid) by Alpha-Pharma Healthcare is a synthetic non-steroidal drug that is very similar in structure to estrogen. Promifen (Clomid) is widely used as an ovulatory stimulant. Because of it’s similarity to estrogen, Promifen (Clomid) can bind to the estrogen receptors in the hypothalamus. This blocks the hypothalamus from sensing “real” estrogen and the hypothalamus in turn acts by stimulating the pituitary to release more Gonadotropins like FSH and LH. The FSH and LH stimulate the ovaries/testes to produce more estrogen/testosterone.
This property of Promifen (Clomid) has been widely used to treat women with ovarian failure and induce ovulation. However, long term use of this drug may not be safe because of the increase risk of ovarian cancer.
Promifen (Clomid) is a large molecule, which is soluble in most organic solvents like alcohol. The sodium salt citrate is also soluble in water. The chemical is odorless. Clomiphene comes as a 50 mg tablet. Patients who receive Promifen (Clomid) must have been fully worked up for all gynecological and endocrine disorders prior to therapy.
Ovulation typically occurs 5-10 days after starting Promifen. This coitus should be timed to coincide with the expected time of ovulation. Clomid is started out at 50 mg/day for 5 days. This dose can be increased in females who do not ovulate.
Promifen (Clomid) is only taken once a day. Experts in the field of body building suggest that it be used alone or in combination with low potency anabolic steroids. Most body builders take anabolic steroids for a few months and then switch over to Clomid. The Promifen (Clomid) provides the surge in testosterone and also prevents the development of breast enlargement. The exact timing of when to start Clomid is not known but it is recommended that once the steroid drugs are stopped, Promifen (Clomid) should be started within 7-10 days.
At the recommended doses for the short duration, Promifen (Clomid) is generally safe. The majority of adverse reactions that occur are transient and disappear once the treatment is stopped.
The most common side effects include the following: flushing, abdominal discomfort, nausea, vomiting, breast tenderness, headaches, abnormal vaginal bleeding, general fatigue, hair loss.